Description

4,4,5,5-Tetramethyl-2-(3-(Trifluoromethyl)Benzyl)-1,3,2-Dioxaborolane is a high-purity, advanced boronic ester building block essential for modern synthetic chemistry. Its core value lies in enabling efficient and selective cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This compound is critically needed by R&D and process development teams in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel active ingredients and functional molecules. Its specific structure offers enhanced stability and reactivity for introducing the valuable 3-(trifluoromethyl)benzyl moiety.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing trifluoromethyl groups for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the trifluoromethylbenzyl group imparts specific biological activity.
• Material Science Research: Serves as a building block for organic electronic materials, such as those used in OLEDs and semiconductors, where precise molecular engineering is required.
• Suzuki-Miyaura Cross-Coupling: The primary application is as a robust boronic ester partner for palladium-catalyzed carbon-carbon bond formation with aryl or vinyl halides.
• Medicinal Chemistry & Drug Discovery: Enables rapid parallel synthesis and library development for screening novel drug candidates in hit-to-lead and lead optimization campaigns.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands or organometallic catalysts for asymmetric synthesis.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-(3-(Trifluoromethyl)Benzyl)-1,3,2-Dioxaborolane
CAS No.	1190235-39-2
Molecular Formula	C₁₆H₂₂BF₃O₂
Molecular Weight	314.16 g/mol
Synonyms	2-(3-(Trifluoromethyl)benzyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (3-(Trifluoromethyl)benzyl)boronic acid pinacol ester; 1,3,2-Dioxaborolane, 2-[(3-(trifluoromethyl)phenyl)methyl]-4,4,5,5-tetramethyl-; 3-(Trifluoromethyl)benzylboronic acid pinacol ester; Pinacol (3-(Trifluoromethyl)benzyl)boronate; (3-(Trifluoromethyl)benzyl)BPin; α-(Trifluoromethyl)benzylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 4,4,5,5-Tetramethyl-2-(3-(Trifluoromethyl)Benzyl)-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (¹H, ¹³C, ¹¹B, ¹⁹F), and GC to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring GMP-grade intermediates and materials for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area Percent)
Purity (GC)	≥96.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.