Description

tert-Butyl 7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound is a critical building block in modern medicinal chemistry, enabling efficient Suzuki-Miyaura cross-coupling reactions to construct complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex heterocyclic compounds for drug discovery programs.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester reagent for carbon-carbon bond formation with aryl/heteroaryl halides.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and the preparation of targeted compound libraries.
• API Development: Integral to the scalable synthesis of candidate molecules for preclinical and clinical development.
• Chemical Biology Probes: Employed in the creation of labeled molecules for target identification and validation studies.
• Agrochemical Research: Potential intermediate in the development of novel active ingredients with specific biological activity.

Basic Information

Product Name	tert-Butyl 7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3,4-Dihydroisoquinoline-2(1H)-Carboxylate
CAS No.	1190058-21-9
Molecular Formula	C20H30BNO4
Molecular Weight	359.27 g/mol
Synonyms	7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; tert-Butyl 7-(pinacolatoboryl)-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; 7-BPin-THIQ-OtBu; 2-Boc-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoquinoline; 1190058-21-9; BOC-7-Pinacolatoboryl-Tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and light-sensitive nature. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.