Description

Thiabendazole-D4 (Benzimidazole-4,5,6,7-D4) is a deuterated internal standard of the widely used fungicide and anthelmintic agent, thiabendazole. This stable isotope-labeled compound is essential for ensuring the accuracy and reliability of quantitative analysis in advanced research and regulatory testing. It is a critical tool for scientists and quality control professionals in the pharmaceutical, agrochemical, and food safety industries who require precise measurement of thiabendazole residues and metabolites.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a high-purity internal standard for the accurate quantification of thiabendazole in complex matrices, minimizing matrix effects and improving data integrity.
• Pharmaceutical Metabolism & Pharmacokinetic (PK) Studies: Used in drug development to track the absorption, distribution, metabolism, and excretion (ADME) of thiabendazole and related benzimidazole drugs.
• Food Safety & Residue Analysis: Critical for regulatory compliance testing to measure thiabendazole pesticide residues in fruits, vegetables, and other agricultural commodities with high precision.
• Environmental Monitoring: Enables the trace-level detection and quantification of thiabendazole in soil and water samples to assess environmental impact and persistence.
• Veterinary Drug Analysis: Employed in the analysis of animal tissues and feed to monitor for thiabendazole and ensure compliance with maximum residue limits (MRLs).
• Method Development & Validation: A cornerstone for developing, calibrating, and validating new analytical methods in compliance with guidelines from FDA, EPA, and other regulatory bodies.

Basic Information

Product Name	Thiabendazole-D4 (Benzimidazole-4,5,6,7-D4)
CAS No.	1190007-20-5
Molecular Formula	C10H3D4N3S
Molecular Weight	205.27 g/mol
Synonyms	Thiabendazole-d4; 2-(1,3-Thiazol-4-yl)-1H-benzimidazole-4,5,6,7-d4; 4-(4,5,6,7-Tetradeuterio-1H-benzimidazol-2-yl)-1,3-thiazole; TBZ-d4; Deuterated Thiabendazole; [2H4]-Thiabendazole; Mintezol-d4 (deuterated analog); EINECS for base compound: 205-725-8

Quality Control

Every batch of Thiabendazole-D4 is manufactured and analyzed under strict quality systems to ensure the high chemical purity and isotopic enrichment required for analytical standards. Our products undergo rigorous quality testing, including NMR and mass spectrometry, to confirm deuteration level and chemical identity. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and analytical methods is provided with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (Mass Spec)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuteration at 4,5,6,7 positions)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.