Description

2-Amino-9H-Pyrido[2,3-β]Indole-15N3 is a stable isotope-labeled analog of a heterocyclic aromatic amine, specifically enriched with nitrogen-15 (15N). This compound serves as a critical internal standard and tracer in advanced analytical and metabolic studies, ensuring unparalleled accuracy in quantitative mass spectrometry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the investigation of mutagenic compounds, drug metabolism, and environmental toxicology.

Application

• Internal Standard for LC-MS/MS: Essential for the precise quantification of heterocyclic aromatic amines (HAAs) and their metabolites in complex biological matrices.
• Metabolic Pathway Tracing: Used in 15N-labeled studies to elucidate the biotransformation and metabolic fate of pyridoindole derivatives.
• Toxicology and Safety Assessment: A key reagent in research focused on the genotoxicity and carcinogenicity of cooked food mutagens.
• Pharmaceutical Reference Material: Supports the development and validation of analytical methods for novel drug candidates with similar core structures.
• Environmental Analysis: Employed in trace-level detection and monitoring of persistent aromatic amines in environmental samples.
• Biochemical Research: Facilitates protein-binding studies and investigations into DNA adduct formation mechanisms.

Basic Information

Product Name	2-Amino-9H-Pyrido[2,3-β]Indole-15N3
CAS No.	1189920-50-0
Molecular Formula	C11H815N3
Molecular Weight	~186.20 g/mol (for 15N3 labeled)
Synonyms	2-Amino-9H-pyrido[2,3-b]indole-15N3; AαC-15N3; 2-Amino-α-carboline-15N3; 2-Amino-9H-pyrido[2,3-b]indole (triple 15N labeled); 2-Amino-α-carboline (triple 15N labeled); 9H-Pyrido[2,3-b]indol-2-amine-15N3; [15N3]-AαC
EINECS	Contact for details

Quality Control

Every batch of 2-Amino-9H-Pyrido[2,3-β]Indole-15N3 is manufactured and analyzed under strict quality management systems. We guarantee high chemical purity and isotopic enrichment as specified. Comprehensive analytical testing, including HPLC, NMR, and Mass Spectrometry, is performed to confirm identity, purity, and isotopic abundance. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This material is light-sensitive (store away from light) and hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Yellow to brown powder or crystalline solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Area %)
Isotopic Enrichment (15N)	≥ 98 atom % 15N
Water Content (KF)	≤ 2.0 %
Residue on Ignition	≤ 0.5 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.