Description

n-Acetyl Sulfamethazine-D4 is a stable isotope-labeled internal standard, specifically a deuterated derivative of the acetylated metabolite of sulfamethazine. This compound is essential for ensuring accuracy and reliability in quantitative mass spectrometry-based analyses, providing a critical reference point for method validation and calibration. It is primarily required by analytical laboratories and research institutions in the pharmaceutical, food safety, and environmental monitoring sectors for precise trace-level detection and quantification of sulfonamide residues.

Application

• Quantitative Mass Spectrometry: Serves as a critical internal standard for the accurate LC-MS/MS or GC-MS analysis of sulfamethazine and its metabolites in complex matrices.
• Pharmaceutical Research & Metabolism Studies: Used in pharmacokinetic and metabolic pathway studies to track and quantify drug-derived compounds with high precision.
• Food Safety & Veterinary Drug Residue Testing: Enables reliable monitoring of sulfamethazine residues in animal-derived food products (meat, milk, honey) to ensure regulatory compliance.
• Environmental Analysis: Applied in the detection and quantification of sulfonamide antibiotic pollutants in water, soil, and waste samples.
• Method Development & Validation: A key component for developing, optimizing, and validating robust analytical methods in compliance with guidelines from agencies like the FDA and EMA.
• Clinical & Diagnostic Assays: Supports the development of high-sensitivity diagnostic tests for therapeutic drug monitoring or exposure assessment.

Basic Information

Product Name	n-Acetyl Sulfamethazine-D4
CAS No.	1189891-99-3
Molecular Formula	C14D4H14N4O4S
Molecular Weight	322.36 g/mol
Synonyms	N4-Acetylsulfadimidine-d4; Sulfadimidine N4-Acetate-d4; Deuterated N-Acetylsulfamethazine; N-Acetyl Sulfadimidine-d4; 4-Acetamido-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide-d4; Sulfamethazine Acetyl-d4; Internal Standard for Sulfamethazine-d4; IS for Sulfonamide Analysis-d4
EINECS	Contact for details

Quality Control

Every batch of n-Acetyl Sulfamethazine-D4 is manufactured and analyzed under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, supported by comprehensive analytical data including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) specifying purity, isotopic purity (D-enrichment), and identity confirmation is provided with each shipment to meet the stringent requirements of analytical reference standard applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.