Description

n-tert-Boc-2-(4-Formyl-2-Methoxyphenoxy)Ethylamine-D3 is a deuterated, Boc-protected amino aldehyde derivative, serving as a critical advanced intermediate in pharmaceutical research and development. Its core value lies in enabling the synthesis of isotopically labeled compounds for use in metabolism studies, pharmacokinetic analysis, and as internal standards for mass spectrometry. This high-purity building block is essential for medicinal chemists and researchers in pharmaceutical, agrochemical, and biotechnology sectors who require precise molecular tools for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of deuterated drug candidates and active pharmaceutical ingredients (APIs).
• Metabolic Tracer Synthesis: Used in creating isotopically labeled compounds for studying drug metabolism and pharmacokinetics (DMPK).
• Mass Spectrometry Standards: Serves as a precursor for high-purity internal standards used in quantitative LC-MS/MS analysis.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies by providing a deuterated aldehyde handle for further derivatization.
• Agrochemical Development: Intermediate in the research and synthesis of novel, labeled agrochemicals.
• Bioconjugation & Probe Development: Useful for creating labeled molecular probes and bioconjugates for diagnostic and research applications.

Basic Information

Product Name	n-tert-Boc-2-(4-Formyl-2-Methoxyphenoxy)Ethylamine-D3
CAS No.	1189481-50-2
Molecular Formula	C15H20D3NO5
Molecular Weight	298.37 g/mol
Synonyms	1-Boc-2-(4-Formyl-2-methoxyphenoxy)ethylamine-d3; 2-[(4-Formyl-2-methoxyphenoxy)]-N-(tert-butoxycarbonyl)ethylamine-d3; tert-Butyl N-[2-[(4-formyl-2-methoxyphenoxy)]ethyl-d3]carbamate; Boc-Vanillylamine-d3 Aldehyde; Deuterated Boc-protected Amino Aldehyde; (4-Formyl-2-methoxyphenoxy)ethyl-1,1,2-d3-amine, N-Boc protected; 2-(4-Formyl-2-methoxyphenoxy)-1-(tert-butoxycarbonylamino)ethane-1,1,2-d3
EINECS	Contact for details

Quality Control

Our n-tert-Boc-2-(4-Formyl-2-Methoxyphenoxy)Ethylamine-D3 is manufactured under strict quality control protocols to ensure high chemical purity and isotopic enrichment suitable for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity (by HPLC/NMR), deuterium incorporation, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and degradation. Keep the container in a cool, dry, and well-ventilated area. Allow the sealed container to reach ambient temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Incorporation (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.