Description

3',5'-Difluoro-4'-(Trifluoromethyl)Acetophenone is a high-value fluorinated aromatic ketone building block, distinguished by its unique trifluoromethyl and difluoro substitution pattern. This compound is essential for introducing lipophilicity and metabolic stability into target molecules, making it a critical intermediate in advanced organic synthesis. It is primarily sought after by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, including kinase inhibitors and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Research: Used in the development of next-generation herbicides and fungicides, leveraging the fluorine atoms for enhanced bioactivity and environmental persistence.
• Material Science Precursor: Serves as a building block for specialty polymers and liquid crystals where fluorine content imparts specific chemical resistance and optical properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, nucleophilic additions, and reductions to construct more complex fluorinated aromatic systems.
• Chemical Biology Probe Development: Utilized in creating labeled compounds and molecular probes for studying biological mechanisms.

Basic Information

Product Name	3',5'-Difluoro-4'-(Trifluoromethyl)Acetophenone
CAS No.	1189359-39-4
Molecular Formula	C9H5F5O
Molecular Weight	224.13 g/mol
Synonyms	1-[3,5-Difluoro-4-(trifluoromethyl)phenyl]ethan-1-one; 3,5-Difluoro-α,α,α-trifluoro-p-acetophenone; 3,5-Difluoro-4-(trifluoromethyl)acetophenone; 3,5-Difluoro-4-trifluoromethylacetophenone; 3',5'-Difluoro-4'-trifluoromethylacetophenone; 4'-(Trifluoromethyl)-3',5'-difluoroacetophenone; Ethanone, 1-[3,5-difluoro-4-(trifluoromethyl)phenyl]-
EINECS	Contact for details

Quality Control

Our 3',5'-Difluoro-4'-(Trifluoromethyl)Acetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and batch-to-batch consistency for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.