Description

2-(Trimethylsilyl)Furo[3,2-B]Pyridine-6-Carbonitrile is a high-value, heterocyclic building block featuring a fused furan-pyridine core with a trimethylsilyl protecting group and a nitrile functional handle. This compound is critical for advanced organic synthesis, enabling the construction of complex molecular architectures with precise regiochemistry. It is primarily utilized by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, including kinase inhibitors and other biologically relevant heterocycles.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, particularly for kinase inhibitor libraries and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its unique heterocyclic scaffold.
• Material Science Precursor: Serves as a specialized monomer or ligand precursor for advanced organic electronic materials and metal-organic frameworks (MOFs).
• Chemical Biology Probe: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Academic & Contract Research: Essential for methodological development in organic chemistry and for custom synthesis projects requiring sophisticated heterocyclic chemistry.

Basic Information

Product Name	2-(Trimethylsilyl)Furo[3,2-B]Pyridine-6-Carbonitrile
CAS No.	1188988-30-8
Molecular Formula	C13H14N2OSi
Molecular Weight	242.35 g/mol
Synonyms	6-Cyano-2-(trimethylsilyl)furo[3,2-b]pyridine; Furo[3,2-b]pyridine-6-carbonitrile, 2-(trimethylsilyl)-; 2-TMS-furo[3,2-b]pyridine-6-carbonitrile; 2-Trimethylsilylfuro[3,2-b]pyridine-6-carbonitrile; 1188988-30-8; 2-(Trimethylsilyl)-6-cyanofuro[3,2-b]pyridine
EINECS	Contact for details

Quality Control

Our 2-(Trimethylsilyl)Furo[3,2-B]Pyridine-6-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.