Description

1-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Benzo[D]Imidazol-2(3H)-One is a high-value, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critical for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl and heterobiaryl scaffolds. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, especially those containing benzimidazole cores with complex substitution patterns.
• Suzuki-Miyaura Cross-Coupling: Serves as a stable, air-handleable boronic ester partner for palladium-catalyzed carbon-carbon bond formation with aryl/heteroaryl halides.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides that require specific heterocyclic architectures.
• Material Science & OLED Development: Acts as a precursor for creating organic electronic materials, ligands for catalysts, and emissive layers in light-emitting devices.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and tool compounds for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring precise boronic ester chemistry.

Basic Information

Product Name	1-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Benzo[D]Imidazol-2(3H)-One
CAS No.	1187968-73-5
Molecular Formula	C16H21BN2O3
Molecular Weight	300.16 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methyl-1,3-dihydro-2H-benzimidazol-2-one; 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-benzimidazolinone; 1-Methyl-5-(pinacolatoboryl)-1H-benzo[d]imidazol-2(3H)-one; 5-(Pinacolatoboryl)-1-methyl-1,3-dihydro-2H-benzimidazol-2-one; 1187968-73-5; Benzimidazolone boronic ester pinacol; 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzoimidazol-2(3H)-one
EINECS	Contact for details

Quality Control

Our production of 1-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Benzo[D]Imidazol-2(3H)-One adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and LC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain product integrity and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.