Description

4-Fluoro-2-(trifluoromethyl)benzamidine is a high-purity benzamidine derivative, a critical building block in modern synthetic organic chemistry. Its value lies in its unique trifluoromethyl and fluoro substituents, which are essential for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly protease inhibitors and other biologically relevant molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially protease inhibitors and enzyme modulators.
• Agrochemical Research: Used in the synthesis of advanced pesticides and herbicides, where the fluorine atoms enhance biological activity and environmental stability.
• Chemical Biology Probe: Serves as a versatile scaffold for creating molecular probes to study enzyme function and protein-protein interactions.
• Material Science Precursor: Potential building block for specialty polymers and advanced materials requiring fluorine-containing aromatic units.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for use in multi-step synthetic routes for client-specific targets.

Basic Information

Product Name	4-Fluoro-2-(Trifluoromethyl)Benzamidine
CAS No.	1187927-54-3
Molecular Formula	C8H6F4N2
Molecular Weight	206.14 g/mol
Synonyms	4-Fluoro-2-(trifluoromethyl)benzenecarboximidamide; 2-Trifluoromethyl-4-fluorobenzamidine; 4-Fluoro-α,α,α-trifluoro-o-toluamidine; Benzenecarboximidamide, 4-fluoro-2-(trifluoromethyl)-; 4-Fluoro-2-trifluoromethylbenzamidine
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-(trifluoromethyl)benzamidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.