Description

(1S,2S,3R,5S)-Pinanedioln-Boc-L-Phenylalanine-L-Leucine Boronate is a sophisticated chiral boronate ester derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in enabling highly stereoselective transformations, particularly in the synthesis of complex peptides and peptidomimetics. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, where precise control over molecular architecture is paramount for developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of protease inhibitors and other bioactive peptide-based drugs.
• Peptidomimetic Synthesis: Enables the construction of stable, drug-like molecules that mimic natural peptides.
• Asymmetric Catalysis: Used as a ligand precursor or reagent in metal-catalyzed asymmetric reactions.
• Medicinal Chemistry Research: A valuable tool for structure-activity relationship (SAR) studies in drug discovery programs.
• Chemical Biology Probes: Facilitates the creation of labeled or modified peptides for studying biological pathways.
• Process Chemistry Development: Supports the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(1S,2S,3R,5S)-Pinanedioln-Boc-L-Phenylalanine-L-Leucine Boronate
CAS No.	1187479-72-6
Molecular Formula	C31H48BNO6
Molecular Weight	541.54 g/mol
Synonyms	Boc-Phe-Leu-Boronate Pinanediol Ester; (1S,2S,3R,5S)-Pinanediol N-Boc-L-Phenylalanyl-L-Leucineboronate; N-(tert-Butoxycarbonyl)-L-phenylalanyl-L-leucine (1S,2S,3R,5S)-(-)-Pinanediol Boronate; L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-, (1S,2S,3R,5S)-3,6,6-trimethyl-2-pinanyl ester, boronate with L-leucine; Boron-Phe(Boc)-Leu-Pinanediol Ester; Peptide Boronic Acid Pinanediol Ester; Chiral Amino Acid Boronate Ester
EINECS	Contact for details

Quality Control

Our production of (1S,2S,3R,5S)-Pinanedioln-Boc-L-Phenylalanine-L-Leucine Boronate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, critical for sensitive pharmaceutical applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.