Description

2-Bromo-5-Iodo-4-Nitrobenzotrifluoride is a high-value, multi-halogenated aromatic building block designed for advanced synthetic chemistry. Its unique trifluoromethyl and halogen substitution pattern makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the bioactivity of the halogenated aromatic core.
• Material Science: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Sonogashira cross-coupling reactions due to the presence of both bromo and iodo leaving groups, allowing for sequential functionalization.
• Fluorine Chemistry: The benzotrifluoride moiety is valuable for modulating lipophilicity, metabolic stability, and bioavailability in drug design.
• Chemical Synthesis: Employed in nucleophilic aromatic substitution and other transformations to introduce complex aromatic systems into target molecules.

Basic Information

Product Name	2-Bromo-5-Iodo-4-Nitrobenzotrifluoride
CAS No.	1187385-82-5
Molecular Formula	C7H2BrF3INO2
Molecular Weight	405.91 g/mol
Synonyms	1-Bromo-2-iodo-5-nitro-4-(trifluoromethyl)benzene; 4-Nitro-2-bromo-5-iodobenzotrifluoride; 2-Bromo-5-iodo-4-nitro-α,α,α-trifluorotoluene; Benzene, 1-bromo-2-iodo-5-nitro-4-(trifluoromethyl)-; 2-Bromo-5-iodo-4-nitrobenzotrifluoride; 4-(Trifluoromethyl)-2-bromo-5-iodonitrobenzene
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and development. Every batch is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) detailing all relevant specifications are available upon request. We adhere to a quality management system to ensure batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flames. Due to its light-sensitive nature, handling should be conducted under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.