Description

4-(2-Bromo-5-(Trifluoromethoxy)Phenyl)-2-Methylbut-3-Yn-2-Ol is a high-value, multi-functional organic intermediate characterized by its unique combination of bromo, trifluoromethoxy, and alkyne functional groups. This compound matters for its role as a critical building block in modern synthetic chemistry, enabling the construction of complex molecular architectures with precision. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for applications in drug discovery, ligand synthesis, and the development of specialty polymers.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and metabolic stability.
• Material Science: Acts as a monomer or cross-linking agent in the production of specialty polymers and advanced organic electronic materials.
• Chemical Synthesis: Utilized in Sonogashira and other palladium-catalyzed cross-coupling reactions to introduce complex arylacetylene units into target molecules.
• Ligand & Catalyst Development: Provides a versatile scaffold for creating novel phosphine or N-heterocyclic carbene (NHC) ligands for asymmetric catalysis.
• Life Sciences & Diagnostics: Employed in the synthesis of molecular probes and fluorescent tags for bioimaging and diagnostic assays.

Basic Information

Product Name	4-(2-Bromo-5-(Trifluoromethoxy)Phenyl)-2-Methylbut-3-Yn-2-Ol
CAS No.	1187385-74-5
Molecular Formula	C12H10BrF3O2
Molecular Weight	323.11 g/mol
Synonyms	2-Methyl-4-[2-bromo-5-(trifluoromethoxy)phenyl]but-3-yn-2-ol; 4-(2-Bromo-5-(trifluoromethoxy)phenyl)-2-methyl-3-butyn-2-ol; 2-Bromo-α,α,α-trifluoro-5-(1-hydroxy-1-methylethyl)phenylethyne; 1-(2-Bromo-5-(trifluoromethoxy)phenyl)-2-methyl-3-butyn-2-ol; 2-Methyl-4-(2-bromo-5-trifluoromethoxyphenyl)-2-butyn-4-ol
EINECS	Contact for details

Quality Control

Every batch of 4-(2-Bromo-5-(Trifluoromethoxy)Phenyl)-2-Methylbut-3-Yn-2-Ol undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocols are designed to meet the stringent requirements of research and scale-up activities. Certificates of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.