Description

(4-(1-(tert-Butoxycarbonyl)-1,2,3,6-Tetrahydropyridin-4-Yl)Phenyl)Boronic Acid Pinacol Ester is a high-value, advanced pharmaceutical intermediate and building block designed for modern synthetic chemistry. This compound matters because it integrates a protected amine and a boronic ester functional group, enabling efficient cross-coupling reactions critical for constructing complex molecules. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for the research and synthesis of novel active ingredients.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key building block for creating biaryl and heterobiaryl structures, which are core scaffolds in many drug candidates.
• Pharmaceutical Intermediate: Used in the research and development of new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Serves as a precursor in the development of novel pesticides and herbicides with complex aromatic architectures.
• Material Science Research: Employed in the synthesis of organic electronic materials and ligands for catalysis.
• Parallel and Combinatorial Chemistry: Ideal for library synthesis due to its stability and reactivity under standard cross-coupling conditions.
• Process Chemistry & Scale-Up: Used in the development of robust, scalable synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(4-(1-(tert-Butoxycarbonyl)-1,2,3,6-Tetrahydropyridin-4-Yl)Phenyl)Boronic Acid Pinacol Ester
CAS No.	1187313-16-1
Molecular Formula	C22H32BNO4
Molecular Weight	385.31 g/mol
Synonyms	4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1,2,3,6-tetrahydropyridine-1-carboxylic acid tert-butyl ester; BOC-4-(4-Bpin-phenyl)-1,2,3,6-tetrahydropyridine; 1-Boc-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1,2,3,6-tetrahydropyridine; tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-3,6-dihydro-2H-pyridine-1-carboxylate; 4-(1-Boc-1,2,3,6-tetrahydropyridin-4-yl)phenylboronic acid pinacol ester.
EINECS	Contact for details

Quality Control

Our (4-(1-(tert-Butoxycarbonyl)-1,2,3,6-Tetrahydropyridin-4-Yl)Phenyl)Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting standards for advanced intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.