Description

4,4,5,5-Tetramethyl-2-(4-propoxy-2-(trifluoromethyl)phenyl)-1,3,2-dioxaborolane is a high-purity, advanced boronic ester building block critical for modern synthetic chemistry. This compound matters because it serves as a key intermediate in cross-coupling reactions, enabling the efficient construction of complex molecules for research and development. It is primarily needed by pharmaceutical, agrochemical, and advanced materials scientists for creating novel active ingredients and functional materials.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of biaryl structures, a common motif in pharmaceuticals and organic electronics.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethyl and aryl ether functionalities.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with enhanced properties.
• Material Science Research: Employed in the development of organic light-emitting diodes (OLEDs), liquid crystals, and polymers requiring specific aryl-boronate components.
• Chemical Biology & Medicinal Chemistry: Utilized in the synthesis of molecular probes and candidate drug molecules for structure-activity relationship (SAR) studies.
• Process Chemistry Development: Acts as a scalable intermediate for optimizing manufacturing routes for complex organic molecules.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-(4-propoxy-2-(trifluoromethyl)phenyl)-1,3,2-dioxaborolane
CAS No.	1186482-12-1
Molecular Formula	C₁₆H₂₂BF₃O₃
Molecular Weight	330.15 g/mol
Synonyms	2-(4-Propoxy-2-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Propoxy-2-(trifluoromethyl)benzeneboronic acid pinacol ester; (4-Propoxy-2-(trifluoromethyl)phenyl)boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-[4-propoxy-2-(trifluoromethyl)phenyl]-1,3,2-dioxaborolane; Pinacol (4-propoxy-2-(trifluoromethyl)phenyl)boronate; CAS 1186482-12-1
EINECS	Contact for details

Quality Control

Our 4,4,5,5-Tetramethyl-2-(4-propoxy-2-(trifluoromethyl)phenyl)-1,3,2-dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and GC analysis, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Assay (NMR)	≥95.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.