Description

1,2-Dibromo-4,5-difluoro-3-nitrobenzene is a highly functionalized, multi-halogenated aromatic building block of significant synthetic utility. Its unique structure, featuring bromine, fluorine, and nitro substituents, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought by researchers and manufacturers in the pharmaceutical and agrochemical sectors for advanced synthesis and material science applications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic cores for bioactivity or as a handle for further functionalization.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine and bromine atoms can enhance metabolic stability and binding affinity.
• Material Science Research: Serves as a monomer or building block for creating specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing nitro and halogen groups.
• Chemical Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) where the bromine atoms act as excellent leaving groups for carbon-carbon and carbon-heteroatom bond formation.
• Fluorinated Compound Library Development: Essential for medicinal chemistry and discovery chemistry programs aiming to explore the benefits of fluorination in drug candidates.

Basic Information

Product Name	1,2-Dibromo-4,5-difluoro-3-nitrobenzene
CAS No.	1481-57-8
Molecular Formula	C6HBr2F2NO2
Molecular Weight	315.88 g/mol
Synonyms	3-Nitro-1,2-dibromo-4,5-difluorobenzene; 4,5-Difluoro-1,2-dibromo-3-nitrobenzene; Benzene, 1,2-dibromo-4,5-difluoro-3-nitro-; 1,2-Dibromo-4,5-difluoronitrobenzene
EINECS	Contact for details

Quality Control

Our 1,2-Dibromo-4,5-difluoro-3-nitrobenzene is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, which includes data from HPLC, GC, NMR, and other relevant techniques. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to the presence of nitro and halogen groups, store separately from strong bases, reducing agents, and combustible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.