Description

7-Trifluoromethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole is a high-value, multi-functional chemical building block essential for modern synthetic chemistry. Its core value lies in the strategic combination of an indazole heterocycle with a pinacol boronate ester group, enabling efficient cross-coupling reactions. This compound is primarily needed by research scientists and process chemists in the pharmaceutical and agrochemical industries for the discovery and development of novel active ingredients. Its trifluoromethyl group is a critical pharmacophore that enhances metabolic stability and membrane permeability in drug candidates.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for constructing complex biaryl structures found in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the indazole scaffold.
• Material Science Research: Serves as a building block for creating novel organic electronic materials, such as those used in OLEDs and semiconductors.
• Medicinal Chemistry: Enables rapid parallel synthesis and library generation for high-throughput screening in drug discovery programs.
• Chemical Biology: Utilized as a probe or tag in the development of enzyme inhibitors and molecular imaging agents.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects requiring specific boronic ester functionalities.

Basic Information

Product Name	7-Trifluoromethyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indazole
CAS No.	1186334-80-4
Molecular Formula	C₁₄H₁₆BF₃N₂O₂
Molecular Weight	312.10 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-7-(trifluoromethyl)-1H-indazole; 7-Trifluoromethyl-1H-indazole-4-boronic acid pinacol ester; 1H-Indazole-4-boronic acid, 7-(trifluoromethyl)-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester; 1186334-80-4; 7-CF3-4-PinB-1H-Indazole; 4-Pinacolatoboryl-7-trifluoromethyl-1H-indazole
EINECS	Contact for details

Quality Control

Our 7-Trifluoromethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformity to client specifications. We support cGMP and ISO standards for pharmaceutical and advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.