Description

2-Triisopropylsilyl-Oxazole-5-Boronic Acid, Pinacol Ester is a sophisticated, high-purity organoboron building block designed for advanced synthetic chemistry. This compound is critical for enabling efficient cross-coupling reactions, particularly in the construction of complex heterocyclic scaffolds. It is an essential reagent for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-quality intermediates for drug discovery and development programs.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for the palladium-catalyzed formation of carbon-carbon bonds, enabling the synthesis of novel oxazole-containing compounds.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), particularly for constructing complex heterocyclic cores prevalent in modern therapeutics.
• Agrochemical Synthesis: Employed in the creation of novel fungicides, herbicides, and insecticides that incorporate the oxazole moiety for enhanced biological activity.
• Material Science Research: Serves as a precursor for organic electronic materials, such as OLEDs and organic semiconductors, where specific heterocyclic structures are required.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and labeled compounds for studying biological pathways and target engagement.
• Process Chemistry & Scale-up: Provides a stable, handleable boronic ester derivative for optimized manufacturing processes of target molecules.

Basic Information

Product Name	2-Triisopropylsilyl-Oxazole-5-Boronic Acid, Pinacol Ester
CAS No.	1186127-11-6
Molecular Formula	C19H36BNO3Si
Molecular Weight	365.40 g/mol
Synonyms	2-[(Triisopropylsilyl)oxy]-1,3-oxazole-5-boronic acid pinacol ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(triisopropylsilyl)oxazole; 2-TIPS-Oxazole-5-Boronic Acid Pinacol Ester; Oxazole-5-boronic acid, 2-(triisopropylsilyl)-, 1,3,2-dioxaborolane ester; TIPS-Protected Oxazole Boronate Ester; 2-TIPS-5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)oxazole; Boronic acid, B-[2-[(triisopropylsilyl)oxy]-1,3-oxazol-5-yl]-, 1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Our 2-Triisopropylsilyl-Oxazole-5-Boronic Acid, Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We employ advanced analytical techniques including NMR, HPLC, and LC-MS for comprehensive characterization. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (NMR)	≥ 97%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.