Description

4-[6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrazin-2-Yl]Morpholine is a high-value, protected boronic ester derivative that serves as a critical synthetic intermediate in modern organic chemistry. Its primary value lies in enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity building blocks for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing pyrazine and morpholine pharmacophores.
• Suzuki-Miyaura Cross-Coupling: Used as a boronic ester coupling partner to form carbon-carbon bonds, enabling the construction of biaryl and heterobiaryl structures prevalent in medicinal chemistry.
• Agrochemical Synthesis: Intermediate in the development of novel herbicides, fungicides, and insecticides that require specific heterocyclic frameworks.
• Material Science Research: Serves as a precursor for organic electronic materials, such as those used in OLEDs and organic semiconductors, where conjugated systems are needed.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Utilized in the modular synthesis of bifunctional molecules for targeted protein degradation research.
• Library Synthesis for High-Throughput Screening: Enables the rapid generation of diverse compound libraries for biological activity screening in drug discovery programs.

Basic Information

Product Name	4-[6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrazin-2-Yl]Morpholine
CAS No.	1186041-99-5
Molecular Formula	C14H22BN3O3
Molecular Weight	291.16 g/mol
Synonyms	4-(6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazin-2-yl)morpholine; 2-Morpholino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazine; 4-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyrazinyl]morpholine; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-morpholinopyrazine; Pinacol 2-Morpholino-5-pyrazinylboronate; 1186041-99-5; 4-(6-(Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazin-2-yl)morpholine
EINECS	Contact for details

Quality Control

Our 4-[6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrazin-2-Yl]Morpholine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistent performance in sensitive cross-coupling applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.