Description

1-Methyl-3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrolo[2,3-B]Pyridine CAS NO 1185427-32-0 is a high-purity, advanced pharmaceutical intermediate featuring a pyrrolopyridine core with a key boronic ester protecting group. This compound is critical for enabling efficient cross-coupling reactions, particularly in the synthesis of complex small molecule APIs. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, including kinase inhibitors and other targeted oncology treatments.

Application

• Suzuki-Miyaura Cross-Coupling Reagent: A key building block for constructing biaryl and heterobiaryl structures in medicinal chemistry.
• Pharmaceutical Intermediate: Used in the research and synthesis of active pharmaceutical ingredients (APIs), especially for kinase-targeted drugs.
• Organic Synthesis Building Block: Enables the introduction of the 1-methyl-1H-pyrrolo[2,3-b]pyridine moiety into complex molecular architectures.
• Agrochemical Research: Serves as a precursor in the development of new crop protection agents and herbicides.
• Material Science Research: Potential use in the synthesis of organic electronic materials and ligands for catalysis.

Basic Information

Product Name	1-Methyl-3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1185427-32-0
Molecular Formula	C14H21BN2O2
Molecular Weight	260.14 g/mol
Synonyms	1-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 1-Methyl-1H-pyrrolo[2,3-b]pyridine-3-boronic acid pinacol ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methyl-1H-pyrrolo[2,3-b]pyridine; 1-Methyl-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 1-Methyl-1H-pyrrolo[2,3-b]pyridine-3-boronic acid, pinacol ester; 1-Methyl-3-(pinacolboryl)-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 1-Methyl-3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided to support research and cGMP development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.