Description

5-Methoxy-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-Tosyl-1H-Indole is a high-value, multi-functional indole derivative containing a pinacol boronate ester group and a tosyl-protected nitrogen. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile Suzuki-Miyaura cross-coupling building block for constructing complex molecular architectures. It is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise, high-purity intermediates for synthesizing novel active compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reactions: Enables the formation of carbon-carbon bonds to attach complex aryl or heteroaryl groups to the indole core.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with tailored properties.
• Material Science: Serves as a precursor for organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology & Proteomics: Utilized as a probe or tag in bioconjugation and target identification studies.
• Academic & Contract Research: A valuable reagent for methodological development and synthetic chemistry research in academic and CRO laboratories.

Basic Information

Product Name	5-Methoxy-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-Tosyl-1H-Indole
CAS No.	1185427-08-0
Molecular Formula	C22H26BNO5S
Molecular Weight	427.32 g/mol
Synonyms	1H-Indole, 5-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-[(4-methylphenyl)sulfonyl]-; 5-Methoxy-1-tosyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indole; 3-Borono-5-methoxy-1-tosylindole pinacol ester; 5-Methoxy-3-(pinacolatoboryl)-1-tosyl-1H-indole; 5-Methoxy-1-(p-toluenesulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole
EINECS	Contact for details

Quality Control

Our 5-Methoxy-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-Tosyl-1H-Indole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ISO standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.