Description

(4-Hydroxy-Piperidin-1-Yl)-Pyrazin-2-Yl-Methanone Hydrochloride is a high-purity, non-natural piperidine derivative with a molecular weight of 243.69. This compound is a critical pharmaceutical intermediate and research chemical valued for its role in the synthesis of novel bioactive molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, particularly for central nervous system (CNS) and metabolic disorder targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its piperidine-pyrazine scaffold.
• Chemical Biology Probe Development: Serves as a precursor for creating tool compounds to study biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production.
• Academic Research: Employed in university and institutional labs for exploratory synthetic chemistry and novel heterocycle development.
• Library Synthesis: Used to generate diverse compound libraries for high-throughput screening (HTS) in drug discovery campaigns.

Basic Information

Item	Details
Product Name	(4-Hydroxy-Piperidin-1-Yl)-Pyrazin-2-Yl-Methanone Hydrochloride
CAS No.	1185309-12-9
Molecular Formula	C10H14ClN3O2
Molecular Weight	243.69 g/mol
Synonyms	1-(Pyrazin-2-ylcarbonyl)-4-hydroxypiperidine hydrochloride; 4-Hydroxy-1-(pyrazine-2-carbonyl)piperidine hydrochloride; 4-Hydroxy-N-(pyrazin-2-yl)piperidine-1-carboxamide hydrochloride; (4-Hydroxypiperidino)(pyrazinyl)methanone hydrochloride; 1-(Pyrazine-2-carbonyl)-4-hydroxypiperidine HCl; 4-Hydroxy-1-piperazinecarbonylpyrazine hydrochloride (common misnomer); 4-Hydroxypiperidine-1-pyrazinyl methanone hydrochloride
EINECS	Contact for details

Quality Control

Our (4-Hydroxy-Piperidin-1-Yl)-Pyrazin-2-Yl-Methanone Hydrochloride is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing to ensure it meets the specified 98+% purity and identity criteria. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, impurities, and other critical parameters. Our quality commitment supports applications requiring research-grade to cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive). For long-term storage, consider desiccants or an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual unknown impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.