Description

1-[3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Pyrrolidin-2-One is a high-value, organoboron building block featuring a pyrrolidinone moiety, designed for advanced synthetic chemistry applications. This compound is critical for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for forming carbon-carbon bonds in complex molecule assembly. It is an essential intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, as well as for material scientists working on organic electronic materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in medicinal chemistry for creating biaryl and heterobiaryl structures.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific, complex aromatic architectures.
• Material Science Research: Serves as a precursor in the development of organic light-emitting diodes (OLEDs), organic photovoltaics (OPVs), and other functional organic electronic materials.
• Chemical Biology & Proteomics: Employed as a versatile handle for bioconjugation and the development of chemical probes and activity-based protein profiling (ABPP) reagents.
• Academic & R&D Laboratories: A valuable reagent for methodological development in cross-coupling chemistry and for constructing complex molecular libraries for screening.
• Ligand & Catalyst Development: Used to synthesize novel bidentate or polydentate ligands for transition metal catalysis.

Basic Information

Product Name	1-[3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Pyrrolidin-2-One
CAS No.	1185265-61-5
Molecular Formula	C16H22BNO3
Molecular Weight	287.16 g/mol
Synonyms	3-(2-Oxopyrrolidin-1-yl)phenylboronic acid pinacol ester; 1-[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyrrolidin-2-one; 3-(2-Oxopyrrolidin-1-yl)benzeneboronic acid pinacol ester; (3-(2-Oxopyrrolidin-1-yl)phenyl)boronic acid pinacol ester; 1-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrrolidin-2-one; 3-Pyrrolidin-1-ylphenylboronic acid pinacol ester (related); Boron, [3-(2-oxo-1-pyrrolidinyl)phenyl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our 1-[3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Pyrrolidin-2-One is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR (1H, 13C, 11B) for structural confirmation, and mass spectrometry to ensure identity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for each lot to support your R&D and quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent moisture absorption and potential hydrolysis of the boronic ester. Ideal storage temperature is between 2°C and 8°C for prolonged stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.