Description

6-(Trifluoromethyl)Isoquinolin-1(2H)-One is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique physicochemical properties imparted by the trifluoromethyl group, which is crucial for modulating the biological activity and metabolic stability of target molecules. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the CF3 group enhances lipophilicity and environmental stability.
• Material Science: Acts as a building block for specialty polymers and advanced organic electronic materials due to its electron-deficient aromatic system.
• Chemical Biology: Employed as a molecular probe or tag in medicinal chemistry to study structure-activity relationships (SAR).
• Custom Synthesis: Utilized by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects requiring fluorinated isoquinoline scaffolds.

Basic Information

Product Name	6-(Trifluoromethyl)Isoquinolin-1(2H)-One
CAS No.	1184916-59-3
Molecular Formula	C10H6F3NO
Molecular Weight	213.16 g/mol
Synonyms	6-(Trifluoromethyl)-1,2-dihydroisoquinolin-1-one; 6-(Trifluoromethyl)-1H-isoquinolin-1-one; 6-Trifluoromethyl-1-isoquinolinone; 1(2H)-Isoquinolinone, 6-(trifluoromethyl)-; 6-Trifluoromethylisoquinolin-1(2H)-one; 6-CF3-Isoquinolin-1-one
EINECS	Contact for details

Quality Control

Our 6-(Trifluoromethyl)Isoquinolin-1(2H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting your R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under inert atmosphere when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.