Description

(2-Bromo-5-Fluorophenyl)Methanesulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its dual functionality, enabling the efficient introduction of both a methanesulfonyl group and a halogenated aryl moiety into target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex molecules for drug discovery and development, especially for sulfonamide-based therapeutics.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides that require specific halogenated aryl-sulfonyl structures.
• Material Science Research: Employed in the development of specialty polymers and advanced organic materials with tailored properties.
• Chemical Biology Probes: Serves as a reagent for modifying proteins or other biomolecules to study biological pathways.
• Cross-Coupling Reactions: Acts as an electrophilic partner in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to construct biaryl systems.
• Sulfonylation Agent: Used to introduce the methanesulfonyl (mesyl) group into nucleophilic substrates like amines and alcohols.

Basic Information

Product Name	(2-Bromo-5-Fluorophenyl)Methanesulfonyl Chloride
CAS No.	1184712-30-8
Molecular Formula	C7H5BrClFO2S
Molecular Weight	287.53 g/mol
Synonyms	2-Bromo-5-fluorobenzenemethanesulfonyl chloride; 1-Bromo-4-fluoro-2-(chlorosulfonylmethyl)benzene; (2-Bromo-5-fluorophenyl)methylsulfonyl chloride; Methanesulfonyl chloride, (2-bromo-5-fluorophenyl)-; 2-Bromo-5-fluoro-α-(chlorosulfonyl)toluene; α-Chlorosulfonyl-2-bromo-5-fluorotoluene
EINECS	Contact for details

Quality Control

Our (2-Bromo-5-Fluorophenyl)Methanesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, oxidizing agents, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.