Description

2-(2,2-Difluoroethoxy)-3-Methoxybenzaldehyde is a specialized aromatic aldehyde building block featuring a difluoroethoxy substituent. This compound is valued for its unique molecular architecture, which combines the reactivity of a benzaldehyde group with the electronic and steric properties imparted by the fluorine atoms. It serves as a critical intermediate in advanced organic synthesis, particularly for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. Researchers and process chemists in the pharmaceutical, agrochemical, and material science industries utilize this high-purity intermediate to construct complex molecules with targeted biological or physical properties.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antiviral compounds.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the difluoroethoxy group can enhance metabolic stability and bioavailability.
• Liquid Crystal & OLED Materials: Serves as a precursor for the synthesis of fluorinated organic compounds used in electronic displays and organic light-emitting diodes (OLEDs).
• Chemical Research & Development: An essential reagent in academic and industrial R&D for exploring new chemical reactions and creating libraries of fluorinated compounds for screening.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke molecules on a commercial scale.

Basic Information

Product Name	2-(2,2-Difluoroethoxy)-3-Methoxybenzaldehyde
CAS No.	1184531-70-1
Molecular Formula	C10H10F2O3
Molecular Weight	216.18 g/mol
Synonyms	3-Methoxy-2-(2,2-difluoroethoxy)benzaldehyde; Benzaldehyde, 2-(2,2-difluoroethoxy)-3-methoxy-; 2-(2,2-Difluoroethoxy)-3-methoxybenzaldehyde; 2-(Difluoroethoxy)-3-methoxybenzaldehyde
EINECS	Contact for details

Quality Control

Every batch of 2-(2,2-Difluoroethoxy)-3-Methoxybenzaldehyde is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support development and commercial projects requiring compliance with cGMP, ICH Q7, and other relevant regulatory guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Keep container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation and moisture uptake. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.