Description

(2S)-Amino-4-Chloro-3,3-Dimethylbutanoic Acid is a high-purity, non-natural amino acid derivative characterized by its chiral center and halogenated side chain. This compound matters as a sophisticated building block for the synthesis of complex pharmaceutical intermediates and bioactive peptides. It is primarily needed by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other targeted therapies.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to incorporate a constrained, chlorinated moiety into peptide backbones, modifying their conformation and biological activity.
• Medicinal Chemistry Research: Serves as a valuable scaffold for structure-activity relationship (SAR) studies in drug discovery projects aiming to modulate protein-protein interactions.
• Bioconjugation: The reactive amino and carboxylic acid groups enable its use as a linker or spacer molecule in the development of antibody-drug conjugates (ADCs) and other bioconjugates.
• Chemical Biology Probes: Utilized in the design and synthesis of chemical probes for investigating enzyme mechanisms and cellular pathways.
• Custom Synthesis: A starting material for the custom manufacturing of specialized fine chemicals and advanced intermediates under cGMP or research-grade conditions.

Basic Information

Product Name	(2S)-Amino-4-Chloro-3,3-Dimethylbutanoic Acid
CAS No.	1182213-77-9
Molecular Formula	C6H12ClNO2
Molecular Weight	165.62 g/mol
Synonyms	(2S)-2-Amino-4-chloro-3,3-dimethylbutanoic acid; L-2-Amino-4-chloro-3,3-dimethylbutyric acid; 4-Chloro-3,3-dimethyl-L-homoserine; 4-Chloro-3,3-dimethyl-L-2-aminobutanoic acid; (S)-2-Amino-4-chloro-3,3-dimethylbutanoic acid; 1182213-77-9; Amino-chloro-dimethylbutanoic acid
EINECS	Contact for details

Quality Control

Our (2S)-Amino-4-Chloro-3,3-Dimethylbutanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets exacting standards for research and pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.