Description

1H-Indole, 3-Methyl-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-purity, advanced pharmaceutical intermediate featuring a strategically positioned pinacol boronate ester group. This compound is essential for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern medicinal chemistry for constructing complex biaryl and heterobiaryl scaffolds. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly those containing indole-based structures with complex substitution patterns.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between its boronate group and aromatic/heteroaromatic halides, crucial for constructing diverse chemical libraries.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require specific indole-derived bioactive cores.
• Material Science & OLED Development: Serves as a precursor for creating organic semiconductors, light-emitting materials, and other functional organic electronic components.
• Chemical Biology & Probe Synthesis: Employed in the creation of molecular probes and labeled compounds for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects requiring precise boronic ester chemistry.

Basic Information

Product Name	1H-Indole, 3-Methyl-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1181825-29-5
Molecular Formula	C15H20BNO2
Molecular Weight	257.14 g/mol
Synonyms	3-Methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; 7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-methyl-1H-indole; 3-Methyl-1H-indol-7-ylboronic acid pinacol ester; (3-Methyl-1H-indol-7-yl)boronic acid pinacol ester; 7-Borono-3-methylindole, pinacol ester; 3-Methyl-7-boronoindole pinacol ester; Boron, [7-(3-methyl-1H-indolyl)]-, pinacol ester
EINECS	Contact for details

Quality Control

Our production of 1H-Indole, 3-Methyl-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. Each lot undergoes comprehensive analysis including HPLC purity determination, NMR spectroscopy for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation and maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.