Description

1-(1-Bromo-2-Methylpropan-2-Yl)-2-Chlorobenzene is a specialized halogenated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique sterically hindered structure, which offers distinct reactivity patterns for constructing complex molecular architectures. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as ligand synthesis and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its halogenated benzene core.
• Ligand and Catalyst Preparation: Serves as a precursor for creating sterically demanding phosphine or N-heterocyclic carbene (NHC) ligands used in transition metal catalysis.
• Material Science Research: Employed in the synthesis of specialty monomers or polymers with tailored properties for advanced materials.
• Cross-Coupling Reactions: Functions as an electrophilic partner in Suzuki, Negishi, or other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological systems and target engagement.

Basic Information

Product Name	1-(1-Bromo-2-Methylpropan-2-Yl)-2-Chlorobenzene
CAS No.	1181738-91-9
Molecular Formula	C11H14BrCl
Molecular Weight	261.59 g/mol
Synonyms	2-Chloro-1-(1-bromo-2-methylpropan-2-yl)benzene; 1-(1-Bromo-2-methyl-2-propyl)-2-chlorobenzene; 2-Chloro-α-(1-bromo-1-methylethyl)benzyl bromide (related); o-Chloro-(1-bromo-2-methyl-2-propyl)benzene; 1-Bromo-2-methyl-2-(2-chlorophenyl)propane; (2-Chlorophenyl)(1-bromo-2-methylpropan-2-yl)methane; Benzene, 1-(1-bromo-2-methyl-2-propyl)-2-chloro-
EINECS	Contact for details

Quality Control

Our 1-(1-Bromo-2-Methylpropan-2-Yl)-2-Chlorobenzene is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development. Each lot undergoes comprehensive analytical characterization, including HPLC, GC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.