Description

(3-Bromo-4-Fluorophenyl)Methanesulfonyl Chloride is a high-purity, multi-functional chemical building block essential for advanced organic synthesis. This compound matters for its role as a key sulfonylation reagent, enabling the precise introduction of the methanesulfonyl group into complex molecular architectures. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of potential drug candidates, particularly in kinase inhibitor and protease inhibitor research.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and pesticides, leveraging the bioactivity of the sulfonamide moiety.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers with unique thermal or chemical resistance properties.
• Chemical Biology Probes: Employed to create activity-based probes (ABPs) for studying enzyme function and mechanism in biological systems.
• Ligand Synthesis for Catalysis: Used to prepare novel sulfonamide-based ligands for transition metal catalysis, enabling new asymmetric transformations.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	(3-Bromo-4-Fluorophenyl)Methanesulfonyl Chloride
CAS No.	1179247-63-2
Molecular Formula	C8H7BrClFO2S
Molecular Weight	301.56 g/mol
Synonyms	3-Bromo-4-fluorobenzenemethanesulfonyl chloride; 1-Bromo-2-fluoro-4-(chlorosulfonylmethyl)benzene; (3-Bromo-4-fluorophenyl)methylsulfonyl chloride; 4-Fluoro-3-bromobenzylsulfonyl chloride; Methanesulfonyl chloride, (3-bromo-4-fluorophenyl)-; (3-Br-4-F-C6H2)CH2SO2Cl
EINECS	Contact for details

Quality Control

Our (3-Bromo-4-Fluorophenyl)Methanesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.