Description

4-(Difluoromethoxy)-3-Fluorobenzene-1-Sulfonyl Chloride is a high-purity, multi-fluorinated aromatic sulfonyl chloride building block. This compound is critical for introducing the unique 4-(difluoromethoxy)-3-fluorophenylsulfonyl moiety into target molecules, enabling the development of advanced materials and pharmaceuticals. It is primarily utilized by research chemists and process development scientists in the agrochemical and pharmaceutical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of sulfonamide-based drug candidates, particularly in areas requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides where the difluoromethoxy and sulfonyl chloride groups confer specific biological activity.
• Material Science Research: Serves as a precursor for functionalized polymers, liquid crystals, or advanced organic frameworks that benefit from fluorinated aromatic segments.
• Chemical Biology Probes: Employed in the synthesis of activity-based probes or labeling reagents targeting specific enzymes or biological pathways.
• Custom Synthesis & Contract Manufacturing: A valuable building block for custom chemical synthesis services catering to R&D and pilot-scale production.

Basic Information

Product Name	4-(Difluoromethoxy)-3-Fluorobenzene-1-Sulfonyl Chloride
CAS No.	1178111-39-1
Molecular Formula	C7H4ClF3O3S
Molecular Weight	260.62 g/mol
Synonyms	3-Fluoro-4-(difluoromethoxy)benzenesulfonyl chloride; 4-(Difluoromethoxy)-3-fluorobenzenesulfonyl chloride; 1-(Chlorosulfonyl)-2-fluoro-4-(difluoromethoxy)benzene; 2-Fluoro-α,α-difluoro-4-(chlorosulfonyl)anisole; 3-Fluoro-4-difluoromethoxybenzenesulfonyl chloride; 1178111-39-1; SCHEMBL23305577
EINECS	Contact for details

Quality Control

Every batch of 4-(Difluoromethoxy)-3-Fluorobenzene-1-Sulfonyl Chloride is manufactured and analyzed under strict quality management protocols. We provide comprehensive Certificates of Analysis (COA) that detail purity, identity, and impurity profiles, ensuring traceability and consistency for your critical R&D and scale-up processes. Our quality systems are designed to support applications requiring high-purity chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.