Description

1-[4-(2,2-Difluoroethoxy)Phenyl]Propan-1-One is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity of the propiophenone scaffold combined with the chemical handle provided by the difluoroethoxy substituent, enabling precise molecular modifications. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries who require specialized intermediates for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of advanced herbicides and pesticides, where the fluorine atoms can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Research: Used in the synthesis of fluorinated organic compounds for electronic applications, where the difluoroethoxy group can influence dielectric and optical properties.
• Organic Ligand & Catalyst Development: Acts as a starting material for creating novel chelating ligands or organocatalysts used in asymmetric synthesis.
• Custom Chemical & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring fluorinated aromatic ketones.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry, including cross-coupling reactions and fluorination chemistry.

Basic Information

Product Name	1-[4-(2,2-Difluoroethoxy)Phenyl]Propan-1-One
CAS No.	1178045-63-0
Molecular Formula	C11H12F2O2
Molecular Weight	214.21 g/mol
Synonyms	4-(2,2-Difluoroethoxy)propiophenone; 1-[4-(2,2-Difluoroethoxy)phenyl]-1-propanone; Propiophenone, 4'-(2,2-difluoroethoxy)-; 4'-(2,2-Difluoroethoxy)propiophenone; 2,2-Difluoroethyl 4-propionylphenyl ether; 1-Propanone, 1-[4-(2,2-difluoroethoxy)phenyl]-
EINECS	Contact for details

Quality Control

Our 1-[4-(2,2-Difluoroethoxy)Phenyl]Propan-1-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and consistency, meeting the stringent requirements for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support compliance with global regulatory frameworks, including REACH.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.