Description

5-Aminopyridine-2-Boronic Acid Pinacol Ester is a high-value, multi-functional organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, particularly Suzuki-Miyaura couplings, to construct complex heterocyclic scaffolds. This compound is critically needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for drug discovery and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing aminopyridine motifs for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides that require specific heterocyclic structures for enhanced efficacy and selectivity.
• Material Science: Serves as a building block for organic electronic materials, such as those used in OLEDs and organic semiconductors, where precise molecular architecture is crucial.
• Chemical Biology & Proteomics: Employed in the development of molecular probes, enzyme inhibitors, and bioconjugation tools due to its reactive boronic ester and amine functional groups.
• Library Synthesis for Drug Discovery: Facilitates the rapid generation of diverse compound libraries via parallel and combinatorial chemistry approaches in medicinal chemistry campaigns.
• Ligand and Catalyst Development: Acts as a precursor for novel bidentate ligands used in asymmetric catalysis and transition metal complexes.

Basic Information

Product Name	5-Aminopyridine-2-Boronic Acid Pinacol Ester
CAS No.	1176723-60-6
Molecular Formula	C11H17BN2O2
Molecular Weight	220.08 g/mol
Synonyms	5-Amino-2-pyridineboronic acid pinacol ester; 2-(5-Aminopyridin-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (5-Aminopyridin-2-yl)boronic acid pinacol ester; 5-Amino-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-5-amine; 5-Amino-2-pyridylboronic acid pinacol ester; PINACOL 5-AMINOPYRIDINE-2-BORONATE; 5-Amino-2-boronopyridine pinacol ester
EINECS	Contact for details

Quality Control

Our 5-Aminopyridine-2-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for critical synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and light-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.