Description

1-Cyclohexyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is a high-purity, advanced pharmaceutical intermediate and versatile synthetic building block. This compound is valued for its role in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries to introduce the pyrazole moiety into target structures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in medicinal chemistry programs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides.
• Material Science Research: Serves as a precursor for creating functional organic materials, including ligands for catalysts and monomers for polymers.
• Cross-Coupling Reactions: Specifically designed as a boronic ester pinacol ester for efficient Suzuki-Miyaura cross-coupling with various aryl/heteroaryl halides.
• Chemical Biology Probes: Utilized in the development of molecular probes and tools for studying biological systems.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Item	Details
Product Name	1-Cyclohexyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
CAS No.	1175275-00-9
Molecular Formula	C₁₅H₂₅BN₂O₂
Molecular Weight	276.19 g/mol
Synonyms	1-Cyclohexyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-Cyclohexyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-Cyclohexyl-4-(pinacolboronato)pyrazole; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-cyclohexyl-1H-pyrazole; 1-Cyclohexyl-1H-pyrazole-4-boronic acid pinacol ester; Pyrazole-4-boronic acid, 1-cyclohexyl-, pinacol ester; 1175275-00-9 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our production of 1-Cyclohexyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All materials are accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support cGMP compliance for advanced intermediates and can provide materials suitable for research through to commercial scale under appropriate quality agreements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture absorption and degradation. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.