Description

3-(Methoxymethyl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is a high-value pyridine-based boronic ester building block essential for modern synthetic chemistry. This compound matters as a versatile intermediate for constructing complex molecules via cross-coupling reactions, enabling the development of advanced materials and pharmaceuticals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs), especially in kinase inhibitor and CNS drug discovery.
• Agrochemical Synthesis: Used to introduce the pyridine-methoxymethyl pharmacophore into next-generation herbicides, fungicides, and insecticides.
• Material Science & OLED Development: Serves as a precursor for creating electron-transport materials, ligands for metal-organic frameworks (MOFs), and complex organic semiconductors.
• Ligand & Catalyst Design: Employed in the synthesis of novel bidentate or tridentate ligands for transition metal catalysis and asymmetric synthesis.
• Chemical Biology & Probe Development: Utilized for labeling and bioconjugation strategies to create molecular probes for target identification and validation.
• Scale-up Process Chemistry: Suitable for optimization and kilogram-scale production under GMP-like conditions for late-stage clinical candidate development.

Basic Information

Item	Details
Product Name	3-(Methoxymethyl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine
CAS No.	1174766-05-2
Molecular Formula	C14H22BNO3
Molecular Weight	263.14 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(methoxymethyl)pyridine; 3-Methoxymethyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine; 3-(Methoxymethyl)pyridine-5-boronic acid pinacol ester; 5-Pinacolatoboryl-3-methoxymethylpyridine; Pyridine, 3-(methoxymethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; CAS 1174766-05-2
EINECS	Contact for details

Quality Control

Our 3-(Methoxymethyl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 11B), and GC/MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full analytical data are provided for each lot. We support development and commercial projects with material suitable for use under cGMP guidelines and can provide regulatory support documentation (DMF, CEP) upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product at 2-8°C under an inert atmosphere (argon or nitrogen) in a cool, dry place. The compound is easily oxidized; therefore, the original container should be flushed with inert gas after each opening to minimize exposure to air and moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.