Description

3'-Fluoro-4'-(trifluoromethoxy)acetophenone is a high-value fluorinated aromatic ketone building block essential for advanced organic synthesis. Its unique structure, featuring both fluorine and trifluoromethoxy substituents, is critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Serves as a precursor for developing advanced herbicides, fungicides, and insecticides where the fluorine and trifluoromethoxy groups enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Material Research: Used in the synthesis of fluorinated organic semiconductors and liquid crystal compounds for electronic displays and devices.
• Advanced Polymer Chemistry: Acts as a monomer or cross-linking agent for producing specialty polymers with unique thermal and chemical resistance properties.
• Chemical Research & Development: A versatile building block for exploring novel fluorination chemistry and creating complex molecular architectures in academic and industrial labs.

Basic Information

Product Name	3'-Fluoro-4'-(trifluoromethoxy)acetophenone
CAS No.	1174006-08-6
Molecular Formula	C9H4F4O2
Molecular Weight	220.12 g/mol
Synonyms	1-[3-Fluoro-4-(trifluoromethoxy)phenyl]ethanone; 3-Fluoro-4-(trifluoromethoxy)acetophenone; 3'-Fluoro-4'-(trifluoromethoxy)acetophenone; 1-(3-Fluoro-4-(trifluoromethoxy)phenyl)ethan-1-one; 3-Fluoro-α,α,α-trifluoro-p-methoxyacetophenone; 3-Fluoro-4-trifluoromethoxyacetophenone; 3-Fluoro-4-(trifluoromethoxy)phenyl methyl ketone
EINECS	Contact for details

Quality Control

Our 3'-Fluoro-4'-(trifluoromethoxy)acetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates under cGMP and ISO guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.