Description

Lithium 2-Hydroxy-4,4,5,5-Tetramethyl-2-(1-Methyl-1H-Pyrazol-4-Yl)-1,3,2-Dioxaborolan-2-Uide is a highly versatile and reactive organoboron reagent, specifically a lithium boronate complex. This compound is critical for enabling advanced cross-coupling reactions, offering superior stability and reactivity compared to traditional boronic acids or esters. It is an essential building block for researchers and manufacturers in pharmaceutical development, agrochemical synthesis, and advanced materials science, where precise carbon-boron bond formation is required.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in complex molecule synthesis, particularly in drug discovery.
• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) for various therapeutic areas.
• Agrochemical Synthesis: Employed in creating novel herbicides, fungicides, and insecticides with specific activity profiles.
• Material Science Research: Serves as a precursor for organic electronic materials, such as those used in OLEDs and semiconductors.
• Chemical Biology & Proteomics: Utilized in the development of bioconjugation tools and activity-based probes.
• Academic & Industrial R&D: A fundamental reagent for methodological development in synthetic organic chemistry laboratories.

Basic Information

Product Name	Lithium 2-Hydroxy-4,4,5,5-Tetramethyl-2-(1-Methyl-1H-Pyrazol-4-Yl)-1,3,2-Dioxaborolan-2-Uide
CAS No.	1173889-20-7
Molecular Formula	C₁₀H₁₆BLiN₂O₃
Molecular Weight	221.01 g/mol
Synonyms	Lithium (1-Methyl-1H-pyrazol-4-yl)trifluoroborate; 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Lithium Salt; 1-Methyl-1H-pyrazole-4-boronic acid, pinacol ester, lithium complex; Lithium 1-Methyl-1H-pyrazol-4-yltrifluoroborate; Pyrazole-4-boronic acid pinacol ester lithium salt; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methyl-1H-pyrazole Lithium Derivative
EINECS	Contact for details

Quality Control

Our production of Lithium 2-Hydroxy-4,4,5,5-Tetramethyl-2-(1-Methyl-1H-Pyrazol-4-Yl)-1,3,2-Dioxaborolan-2-Uide adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including NMR (¹H, ¹³C, ¹¹B), HPLC, and elemental analysis, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory requirements for R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a freezer. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures will compromise purity and reactivity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
NMR Purity (¹H)	≥ 97%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.