Description

(R)-4A-Methyl-2,5-Dioxo-2,3,4,4A,5,6,7,8-Octahydro-Naphthalene-1-Carboxylic Acid Ethyl Ester is a high-purity chiral building block and advanced pharmaceutical intermediate of significant synthetic value. Its defined stereochemistry and functionalized decalin core make it a critical precursor for the synthesis of complex, biologically active molecules. This compound is essential for research and development chemists in the pharmaceutical and fine chemical industries, particularly those focused on creating novel therapeutics, agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, particularly in steroid-like or terpenoid-based therapeutic areas.
• Asymmetric Synthesis: Used as a starting material or intermediate in catalytic asymmetric reactions to construct molecules with high enantiomeric purity.
• Agrochemical Research: Serves as a building block for developing novel active ingredients with specific stereochemical requirements.
• Fine Chemical Production: Employed in the custom synthesis of specialty chemicals, flavors, and fragrances requiring a defined (R)-configuration.
• Academic & R&D: A valuable compound for methodological development in organic synthesis and medicinal chemistry research.
• Material Science Precursor: Potential use in synthesizing specialized polymers or liquid crystals with chiral properties.

Basic Information

Product Name	(R)-4A-Methyl-2,5-Dioxo-2,3,4,4A,5,6,7,8-Octahydro-Naphthalene-1-Carboxylic Acid Ethyl Ester
CAS No.	1173675-23-4
Molecular Formula	C₁₄H₁₈O₄
Molecular Weight	250.29 g/mol
Synonyms	(4aR)-4a-Methyl-2,5-dioxo-1,2,3,4,4a,5,6,7-octahydronaphthalene-1-carboxylic acid ethyl ester; Ethyl (4aR)-4a-methyl-2,5-dioxo-3,4,4a,5,6,7-hexahydro-2H-naphthalene-1-carboxylate; (R)-4a-Methyl-2,5-dioxo-2,3,4,4a,5,6,7,8-octahydronaphthalene-1-carboxylic acid ethyl ester; (R)-4a-Methyl-2,5-dioxooctahydronaphthalene-1-carboxylic acid ethyl ester; (R)-Ethyl 4a-methyl-2,5-dioxo-1,2,3,4,4a,5,6,7-octahydronaphthalene-1-carboxylate
EINECS	Contact for details

Quality Control

Our production of (R)-4A-Methyl-2,5-Dioxo-2,3,4,4A,5,6,7,8-Octahydro-Naphthalene-1-Carboxylic Acid Ethyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided with every shipment, supporting compliance in GMP-aligned applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from direct light sources to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.