Description

Difloxacin-D3 is a deuterium-labeled analog of the veterinary fluoroquinolone antibiotic difloxacin, serving as a critical internal standard for precise analytical quantification. This high-purity, isotopically labeled compound is essential for ensuring accuracy and reliability in mass spectrometry-based methods, eliminating variability and enhancing data integrity. It is primarily required by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in veterinary drug residue analysis, pharmacokinetic studies, and metabolic research.

Application

• Internal Standard for LC-MS/MS: Used as a stable isotope-labeled internal standard for the accurate quantification of difloxacin in complex biological matrices (e.g., plasma, tissue, milk).
• Veterinary Drug Residue Testing: Critical for compliance testing in food safety to monitor and quantify difloxacin residues in meat, eggs, and other animal-derived products.
• Pharmacokinetic & Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in veterinary medicine research.
• Method Development & Validation: Supports the development, optimization, and validation of robust analytical methods in regulatory and quality control laboratories.
• Reference Material: Serves as a certified reference material (CRM) for calibrating instruments and ensuring analytical method accuracy.

Basic Information

Product Name	Difloxacin-D3
CAS No.	1173147-93-7
Molecular Formula	C21H16D3F2N3O3
Molecular Weight	398.39 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-7-(4-ethyl-1-piperazinyl)-5,8-dihydro-8-oxo-1,4-dihydro-4-oxoquinoline-3-carboxylic acid-d3; 6-Fluoro-1,4-dihydro-1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid-d3; Difloxacin (methyl-d3); [2H3]-Difloxacin; Deuterated Difloxacin
EINECS	Contact for details

Quality Control

Every batch of Difloxacin-D3 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high standards required for use as an internal standard, including isotopic purity and chemical purity. A detailed Certificate of Analysis (COA) specifying results for assay, isotopic enrichment, and related substances is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.