Description

(E)-Ethyl 3-(4-Bromo-3-Fluorophenyl)Acrylate CAS NO 1173119-94-2 is a high-purity, functionalized acrylate ester building block featuring a bromo-fluorophenyl substituent. This compound is valued for its role as a key intermediate in advanced organic synthesis, particularly in cross-coupling reactions and the construction of complex molecular scaffolds. It is primarily utilized by research and development chemists and process scale-up teams in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), especially those targeting specific receptors or requiring halogenated aromatic systems.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the bromo-fluoro substitution pattern can enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to form complex biaryl structures.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new synthetic methodologies and creating compound libraries for screening.
• Fluorescent Probe & Dye Synthesis: The conjugated acrylate system can be utilized to construct fluorophores and chromophores for imaging and sensing applications.

Basic Information

Product Name	(E)-Ethyl 3-(4-Bromo-3-Fluorophenyl)Acrylate
CAS No.	1173119-94-2
Molecular Formula	C11H10BrFO2
Molecular Weight	273.10 g/mol
Synonyms	Ethyl (E)-3-(4-Bromo-3-fluorophenyl)acrylate; (E)-Ethyl 3-(4-Bromo-3-fluorophenyl)propenoate; 4-Bromo-3-fluorocinnamic Acid Ethyl Ester; trans-Ethyl 3-(4-Bromo-3-fluorophenyl)acrylate; 2-Propenoic acid, 3-(4-bromo-3-fluorophenyl)-, ethyl ester, (E)-; Ethyl (E)-3-(4-Bromo-3-fluorophenyl)-2-propenoate; 1173119-94-2; Ethyl 4-Bromo-3-fluorocinnamate
EINECS	Contact for details

Quality Control

Our (E)-Ethyl 3-(4-Bromo-3-Fluorophenyl)Acrylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.