Description

5-Isopropoxypyridine-3-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. This compound is valued for its role as a key coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the discovery and production of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling: Serves as a stable, air- and moisture-tolerant boronic ester reagent for palladium-catalyzed C-C bond formation with aryl/heteroaryl halides or triflates.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require functionalized pyridine cores.
• Material Science & OLED Development: Employed in the creation of organic electronic materials, including ligands for metal-organic frameworks (MOFs) and emissive layers in organic light-emitting diodes (OLEDs).
• Ligand & Catalyst Preparation: Acts as a precursor for synthesizing specialized bidentate or tridentate ligands used in homogeneous catalysis.
• Chemical Biology & Probe Development: Useful for labeling biomolecules or creating chemical probes for studying biological pathways and protein interactions.

Basic Information

Product Name	5-Isopropoxypyridine-3-Boronic Acid Pinacol Ester
CAS No.	1171892-42-4
Molecular Formula	C15H24BNO3
Molecular Weight	277.17 g/mol
Synonyms	5-Isopropoxy-3-pyridineboronic acid pinacol ester; (5-Isopropoxypyridin-3-yl)boronic acid pinacol ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-isopropoxypyridine; 5-(Propan-2-yloxy)pyridine-3-boronic acid pinacol ester; 5-Isopropoxy-3-pyridylboronic acid pinacol ester; Boronic acid, B-(5-isopropoxy-3-pyridinyl)-, 1,1,1,1-tetramethyl-2-propyl ester; 1171892-42-4.
EINECS	Contact for details

Quality Control

Our 5-Isopropoxypyridine-3-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system adheres to cGMP principles where applicable, supporting its use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.