Description

4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is a high-value organoboron building block, specifically a pyridine-substituted pinacol boronic ester, essential for modern synthetic chemistry. Its core value lies in enabling efficient carbon-carbon and carbon-heteroatom bond formation via cross-coupling reactions, such as the Suzuki-Miyaura reaction, which is critical for constructing complex molecular architectures. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and oncology.
• Agrochemical Synthesis: Used to construct novel pyridine-based herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Ligand and Catalyst Development: Serves as a building block for creating sophisticated ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to the electron-deficient pyridine core.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes and drug-target interactions.
• Scale-up and Process Chemistry: Suitable for transition from laboratory-scale discovery to pilot and commercial-scale manufacturing of fine chemicals.

Basic Information

Product Name	4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
CAS No.	1171891-31-8
Molecular Formula	C₁₃H₂₀BNO₂
Molecular Weight	233.11 g/mol
Synonyms	3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-picoline; 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl)pyridine; 3-Pyridineboronic acid, 4-methyl-, 1,3,2-dioxaborolane ester; 4-Methyl-3-pyridinylboronic acid pinacol ester; 4-Methylpyridin-3-ylboronic acid pinacol ester; Boronic acid, B-(4-methyl-3-pyridinyl)-, 1,1-dimethylethyl ester (9CI); (4-Methylpyridin-3-yl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our production of 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and GC-MS, to verify identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.