Description

3-Acetylamino-n-[5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)Pyridin-3-Yl]Propionamide is a high-value, advanced pharmaceutical intermediate featuring a pyridine core and a pinacol boronate ester functional group. This compound is critical for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of new active pharmaceutical ingredients (APIs), particularly for oncology and central nervous system (CNS) targets.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, especially those requiring complex heterocyclic architectures.
• Suzuki-Miyaura Cross-Coupling Reagent: The pinacol boronate ester group enables efficient, palladium-catalyzed carbon-carbon bond formation with aryl or heteroaryl halides.
• Medicinal Chemistry Research: Used in high-throughput screening libraries and structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• API Development: Integral to process chemistry for scaling up the production of target molecules during clinical development phases.
• Chemical Biology Probes: Can be utilized to create labeled compounds for studying biological pathways and target engagement.
• Agrochemical Research: Potential intermediate in the development of new herbicides or fungicides with novel modes of action.
• Material Science: May be employed in the synthesis of organic electronic materials or metal-organic frameworks (MOFs) due to its conjugated system and functional handles.

Basic Information

Product Name	3-Acetylamino-n-[5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)Pyridin-3-Yl]Propionamide
CAS No.	1171891-27-2
Molecular Formula	C18H28BN3O4
Molecular Weight	361.25 g/mol
Synonyms	N-[3-Acetamidopropyl]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carboxamide; 3-Acetamido-N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl]propanamide; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinamide derivative; Boronic ester pyridine intermediate; Pinacol boronate pyridine amide
EINECS	Contact for details

Quality Control

Our production of 3-Acetylamino-n-[5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)Pyridin-3-Yl]Propionamide adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical research and development applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR (1H, 13C, 11B), and mass spectrometry. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent hydrolysis of the boronate ester group. For long-term storage, consider desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.