Description

Mk-0249 is a high-purity, non-natural amino acid derivative and a key chiral building block in advanced pharmaceutical synthesis. Its precise stereochemistry and functional groups make it an essential intermediate for constructing complex, biologically active molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in the fields of oncology and metabolic diseases.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new active pharmaceutical ingredients (APIs).
• Peptidomimetic Drug Discovery: Used in the design and synthesis of peptide analogs and mimetics to improve metabolic stability and bioavailability.
• Protease Inhibitor Synthesis: Serves as a core structural component in the creation of specific enzyme inhibitors.
• Chemical Biology Research: Employed as a molecular tool for studying protein-protein interactions and enzyme mechanisms.
• Asymmetric Synthesis: Utilized as a starting material or auxiliary in catalytic asymmetric reactions to introduce chirality.
• Pre-clinical Candidate Optimization: Integral to medicinal chemistry efforts for lead optimization and structure-activity relationship (SAR) studies.

Basic Information

Product Name	Mk-0249
CAS No.	1167574-41-5
Molecular Formula	C10H12N2O3S
Molecular Weight	240.28 g/mol
Synonyms	(2S)-2-Amino-3-(4-sulfamoylphenyl)propanoic acid; L-4-(Sulfamoyl)phenylalanine; (S)-2-Amino-3-(4-sulfamoylphenyl)propanoic acid; MK 0249; MK0249; UNII-9V3C5U71Q4; 9V3C5U71Q4; BDBM50111089; SCHEMBL154062; CHEMBL3183092; AKOS009158932
EINECS	Contact for details

Quality Control

Every batch of Mk-0249 is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are supplied with each shipment, detailing key parameters such as chiral purity, chemical purity, and residual solvents. Our quality standards are designed to meet the rigorous demands of pharmaceutical R&D and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.