Description

3-Chloro-4-Methoxyphenylboronic Acid Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for drug discovery and fine chemical synthesis.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aryl halides and this boronic ester, fundamental in creating biphenyl and heterobiaryl scaffolds.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of active pharmaceutical ingredients (APIs), particularly those containing substituted biphenyl or aromatic ether motifs.
• Agrochemical Product Development: Employed in the synthesis of novel herbicides, fungicides, and insecticides that require specific chlorinated methoxy-phenyl structures.
• Ligand and Catalyst Preparation: Acts as a precursor for synthesizing specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Utilized in the development of organic electronic materials, such as those for OLEDs and semiconductors, where precise aromatic building blocks are needed.
• Chemical Biology & Probe Development: Serves as a versatile handle for bioconjugation and the creation of molecular probes for diagnostic and research applications.

Basic Information

Item	Details
Product Name	3-Chloro-4-Methoxyphenylboronic Acid Pinacol Ester
CAS No.	1165936-01-5
Molecular Formula	C₁₃H₁₈BClO₃
Molecular Weight	268.54 g/mol
Synonyms	3-Chloro-4-methoxyphenylboronic acid pinacol ester; (3-Chloro-4-methoxyphenyl)boronic acid pinacol ester; 2-(3-Chloro-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Chloro-4-methoxybenzeneboronic acid pinacol ester; B-(3-Chloro-4-methoxyphenyl)boronic acid pinacol ester; Pinacol (3-chloro-4-methoxyphenyl)boronate
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-4-Methoxyphenylboronic Acid Pinacol Ester is produced and tested under strict quality management protocols to ensure consistency and reliability for your critical syntheses. Our standard grade typically meets a purity specification of ≥95% (by HPLC), with rigorous control of key impurities. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.