Description

2-(2-Fluoro-3-Methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is a high-purity boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its value lies in enabling efficient carbon-carbon bond formation, specifically in the Suzuki-Miyaura cross-coupling reaction, which is fundamental for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-quality intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated biaryl motifs.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides that require specific fluorinated phenyl structures.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where precise molecular engineering is crucial.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura cross-coupling to form biaryl bonds efficiently and under mild conditions.
• Chemical Biology Probes: Acts as a building block for synthesizing fluorinated probes and tags used in bioimaging and diagnostic assays.
• Library Synthesis for Drug Discovery: Enables the rapid, parallel synthesis of diverse compound libraries for high-throughput screening in medicinal chemistry.

Basic Information

Product Name	2-(2-Fluoro-3-Methoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1165936-00-4
Molecular Formula	C13H18BFO3
Molecular Weight	252.09 g/mol
Synonyms	2-Fluoro-3-methoxyphenylboronic acid pinacol ester; (2-Fluoro-3-methoxyphenyl)boronic acid pinacol ester; 2-Fluoro-3-methoxybenzeneboronic acid pinacol ester; Pinacol (2-fluoro-3-methoxyphenyl)boronate; 2-(2-Fluoro-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-Fluoro-3-methoxybenzeneboronic acid, pinacol ester; 2-Fluoro-3-methoxyphenyl-Bpin; B-(2-Fluoro-3-methoxyphenyl)pinacolboronate
EINECS	Contact for details

Quality Control

Our 2-(2-Fluoro-3-Methoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high purity and consistent performance in sensitive cross-coupling applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong acids/bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
NMR Purity (1H NMR)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.