Description

2-Chloro-4-(Trifluoromethyl)Phenylboronic Acid Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the development of new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially those containing trifluoromethyl and chloro-substituted biphenyl scaffolds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the specific halogen and fluorine substitution patterns confer desirable biological activity.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where its structure allows for fine-tuning of electronic properties.
• Chemical Biology Probes: Acts as a versatile handle for bioconjugation and the synthesis of molecular probes used in diagnostic and imaging applications.
• Catalyst & Ligand Development: Serves as a starting material for creating specialized ligands and catalysts used in asymmetric synthesis and other catalytic processes.

Basic Information

Product Name	2-Chloro-4-(Trifluoromethyl)Phenylboronic Acid Pinacol Ester
CAS No.	1165935-98-7
Molecular Formula	C₁₃H₁₅BClF₃O₂
Molecular Weight	306.52 g/mol
Synonyms	2-Chloro-4-(trifluoromethyl)benzeneboronic acid pinacol ester; (2-Chloro-4-(trifluoromethyl)phenyl)boronic acid pinacol ester; 4-Chloro-α,α,α-trifluoro-o-tolylboronic acid pinacol ester; Pinacol [2-chloro-4-(trifluoromethyl)phenyl]boronate; B-[2-Chloro-4-(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-Chloro-4-trifluoromethylphenylboronic acid pinacol ester; CAS 1165935-98-7
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-(Trifluoromethyl)Phenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided to guarantee consistency and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.