Description

4-Chloro-3-Cyanophenylboronic Acid, Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative. This compound is a crucial protected intermediate in modern cross-coupling reactions, offering enhanced stability and handling characteristics compared to its free boronic acid counterpart. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key building block for the palladium-catalyzed formation of biaryl and heterobiaryl bonds, a cornerstone of modern medicinal chemistry.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), particularly for creating novel drug candidates with specific aryl-aryl linkages.
• Agrochemical Synthesis: Serves as a precursor in the development of new herbicides, fungicides, and insecticides requiring structurally complex aromatic components.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as those used in OLEDs and organic photovoltaics, where precise molecular structure controls function.
• Ligand and Catalyst Development: Acts as a starting material for synthesizing specialized ligands and organometallic catalysts.
• Chemical Biology Probes: Useful in constructing molecules for studying biological processes and protein interactions.

Basic Information

Product Name	4-Chloro-3-Cyanophenylboronic Acid, Pinacol Ester
CAS No.	1165935-87-4
Molecular Formula	C₁₃H₁₅BClNO₂
Molecular Weight	263.53 g/mol
Synonyms	4-Chloro-3-cyanophenylboronic acid pinacol ester; (4-Chloro-3-cyanophenyl)boronic acid pinacol ester; 2-(4-Chloro-3-cyanophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Chloro-3-cyanobenzeneboronic acid pinacol ester; Pinacol (4-Chloro-3-cyanophenyl)boronate; B-(4-Chloro-3-cyanophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-Cyanophenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided to guarantee batch-to-batch consistency and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation and to minimize moisture uptake. Recommended storage temperature: 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.