Description

2-[4-Chloro-2-(Trifluoromethyl)Phenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its value lies in enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethyl and chloro-substituted aromatic systems.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that leverage its unique halogenated aryl structure.
• Material Science Research: Serves as a monomer or building block for creating advanced polymers, liquid crystals, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: Primarily employed as a stable, air-handleable boronic ester reagent for palladium-catalyzed carbon-carbon bond formation.
• Chemical Library Development: Utilized in medicinal chemistry for the parallel synthesis and diversification of compound libraries for high-throughput screening.
• Catalyst and Ligand Development: Acts as a synthetic intermediate for creating novel organoboron-based catalysts and ligands.

Basic Information

Item	Details
Product Name	2-[4-Chloro-2-(Trifluoromethyl)Phenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1165935-85-2
Molecular Formula	C13H15BClF3O2
Molecular Weight	306.52 g/mol
Synonyms	4-Chloro-2-(trifluoromethyl)phenylboronic acid pinacol ester; (4-Chloro-2-(trifluoromethyl)phenyl)boronic acid pinacol ester; 2-(4-Chloro-2-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Chloro-2-trifluoromethylbenzeneboronic acid pinacol ester; Pinacol [4-chloro-2-(trifluoromethyl)phenyl]boronate; 1165935-85-2; 4-Chloro-α,α,α-trifluoro-o-tolylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-[4-Chloro-2-(Trifluoromethyl)Phenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high purity and consistent performance for critical synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.