Description

1-Cyclopropyl-2,2-difluoroethan-1-amine hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique cyclopropyl and difluoroethylamine structure. This compound is of significant commercial value for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular modification. It is primarily sought by research institutions and manufacturers in the global pharmaceutical and agrochemical sectors for developing next-generation small molecule drugs and crop protection agents. The hydrochloride salt form enhances stability and handling for synthetic applications.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel drug candidates, especially in medicinal chemistry programs targeting CNS disorders, antivirals, and anti-infectives.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where the cyclopropyl and fluorine motifs contribute to biological activity and environmental stability.
• Chemical Research & Development: Serves as a versatile synthon in academic and industrial R&D for exploring new chemical spaces and reaction methodologies.
• Ligand and Catalyst Preparation: Employed in the preparation of specialized ligands and organocatalysts for asymmetric synthesis and other catalytic processes.
• Material Science Precursor: Potential use in the synthesis of functionalized materials and specialty polymers requiring amine functionality.

Basic Information

Product Name	1-Cyclopropyl-2,2-Difluoroethan-1-Amine Hydrochloride
CAS No.	1160756-86-4
Molecular Formula	C5H10ClF2N
Molecular Weight	157.59 g/mol
Synonyms	1-Cyclopropyl-2,2-difluoroethylamine hydrochloride; α-Cyclopropyl-2,2-difluoroethylamine HCl; 2,2-Difluoro-1-cyclopropylethanamine hydrochloride; (2,2-Difluoro-1-cyclopropylethyl)amine hydrochloride; 1-Amino-2,2-difluoro-1-cyclopropylethane hydrochloride; Cyclopropanemethanamine, 2,2-difluoro-, hydrochloride; 1160756-86-4
EINECS	Contact for details

Quality Control

Every batch of 1-Cyclopropyl-2,2-difluoroethan-1-amine hydrochloride is manufactured under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation, meeting the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator to prevent degradation. Keep away from incompatible materials such as strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.